VETS1032 Lecture Notes - Lecture 16: Glutamate Dehydrogenase, Protein Tertiary Structure, Keto Acid
22 Jul 2018
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Stage 1 : catabolism of protein: extracellular denaturation and proteolysis. Proteins denature from a tertiary conformation to a primary or secondary conformation. The protein denaturation is not irreversible rather much like ph it can reverse back into a tertiary conformation. Also in the stomach enzyme catalysed proteolysis begins. It is alpha ketoacid once the amino group is removed. these alpha ketoacids (carbon skeleton) degrade into common metabolic intermediate (pyruvate, acetlycoa and citric acid cycle) transfer of that amino acid (alpha ketogluterate). The: amino nitrogen is transferred from aa and moved to intermediate of the citric acid to alphaketogluterate and the alpha keto acid (carbon skeleton) forms the amino acid glutamate. Alpha keto glutarate can be reused in either the citric acid cycle or deamination: ammonia is converted to urea by the urea cycle, excpetions are serine and threonine, can be directly deaminated, two types ketogenic and glucogenic.
