PCOL3012 Lecture Notes - Lecture 14: Pyridoxine, Coordinate Covalent Bond, Pentetic Acid
Document Summary
Lecture outline: heavy metal poisoning, how chelatin therapy works, chelating agents in use, endogenous chelators. Many more people (estimates of 20,000) suffered degenerative neurological problems, vision and hearing loss. Dimethylmercury: potent neurotoxin (inhibits key stages in neurotransmission, cumulative poison, readily crosses the blood-brain barrier (via a purported methylmercury-cysteine complex, hg2+ (soft acid) will bind to s-containing (soft base) molecules. Liquid at room temperature with a faint sweet smell. Kinetics vary with: oxidation state, chemical from. Principle: chelator competes with target binding sites for metal. The ideal chelator: an ideal chelation agent will, have ligand groups specific toward the metal, be polydentate, form, metal-complexes > stability than metal-natural substrate, be easily excreted, be non toxic. Chelators in practice: use is rare usually confined to hospital situations, most agents do not appear in mims, some are imported under special license. Donate electron pair to positively charged metal ion to form a coordinate bond (ca 2. 0 ) (eg,
