PCOL2605 Lecture Notes - Lecture 8: Norepinephrine Transporter, Sympathetic Nervous System, Adrenal Medulla
23 Oct 2018
School
Department
Course
Professor
Document Summary
Relating to the actions of adrenaline and noradrenaline. The neurotransmitter released by most postganglionic sympathetic nerve fibres is noradrenaline. Remember the neurotransmitter released by postganglionic sympathetic nerve fibres in sweat glands is ach. Around 75% of released noradrenaline is taken back up into the nerve and recycled - norepinephrine transporter (net) Enzymatic breakdown of noradrenaline (mao and comt) Noradrenaline also acts on presynaptic (alpha2) receptors to regulate its own release. Noradrenaline released from sympathetic postganglionic adrenergic nerve endings. Adrenaline and noradrenaline released from the adrenal medulla. Other adrenergic compounds which may selectively stimulate some receptor types. They are divided into alpha and beta, which are further divided into the following subtypes: Drugs used therapeutically to stimulate alpha1 adrenoceptors (act as agonists) include: Adrenaline sometimes added to local anaesthetic preparations. Agonist on alpha 1 adrenoceptors on blood vessels produces vasoconstriction and prolongs the action of the local anaesthetic by keeping it at the site of action.
