PHAR3819 Lecture Notes - Lecture 14: Alcoholic Liver Disease, Glycogen Storage Disease, Hepatic Encephalopathy
23 Jul 2018
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Document Summary
Cirrhosis is scarring of the liver that involves the formation of fibrous (scar) tissue associated with the destruction of the normal architecture of the organ. Chronic diffuse liver disease characterized by hepatic fibrosis and nodule formulation. Liver cell necrosis and collapse of reticulum framework. Alcoholic liver disease hepatitis c plus alcoholic liver disease: hepatitis b, which may be coincident with hepatitis d. Type iv glycogen storage disease: drug-induced liver disease (e. g. methotrexate, alpha methyldopa, amiodarone) Venous outflow obstruction (e. g. budd-chiari syndrome, veno-occlusive disease) Broad fibrous bands of varying thickness surround the large nodules: mixed. The diagnosis of cirrhosis is generally made on the basis of the symptoms and physical examination, together with a history of risk factors such as alcohol abuse. The liver can carry out essential functions even when its total activity is 85% below normal. Care - e. g. doses of drugs metabolised by the liver: nutrition - controlling protein intake, monitoring.
