MBLG2972 Lecture Notes - Lecture 16: P1 Phage, Prophage, Lambda Phage

• School: University of Sydney
• Department: Microbiology
• Course: MBLG2972
• Professor: Professor Mary B

Document Summary

Icosahedral head, hollow protein sheath, some have tail bers. Replication and gene expression require enzymes from host cell. Allows for genetic material to enter a recipient cell via a bacteriophage. Donor dna can be included in the phage chromosome. Progeny phage then infect a recipient cell, inject the donor dna. Use bacterial proteins as a means of entry. Lytic cycle (lysis of the host cell): attachment of the phage to the host cell. Injection of the phage chromosome into the host: replication of phage dna, transcription and translation of phage genes, packaging of phage chromosome into phage heads, lysis of the host cell, release of progeny phage particles. Due to rare errors in packaging of phage dna during the lytic cycle: bacteriophage can"t choose which dna it wants to put into its head, therefore sometimes the degrading host dna becomes mixed with viral dna.