EXSS3024 Lecture Notes - Lecture 9: Hypotension, Beta Blocker, Cardiopulmonary Rehabilitation

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Atherosclerosis will show changes in the inner wall of the artery; hardens, ruptures & breaks off. Ischemia = mismatch between how much o2 the body needs & how much can be supplied to the heart to meet demand cells starved of o2. Etiology & pathophysiology: progression of disease occurs over decades, symptoms often precede diagnosis. In latter stages: calcification, rupture of plaque, thrombosis, some people are more susceptible to atherosclerosis than others (have increased. Rf so at more risk: symptoms appear then are confirmed (go undiagnosed for a while) Cv physiology: cardiac work & myocardial vo2 (mvo2, mvo2 is determined by cardiac work (work of the heart) Intramyocardial wall tension (left ventricular pressure x end diastolic volume), contractility & hr: mvo2 = hr x sbp. Amount of o2 required by the heart muscle. If task requires big increase in hr/bp = big increase in rpp.

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