EXSS2028 Lecture Notes - Lecture 5: Cyclic Adenosine Monophosphate, Adenylyl Cyclase, Glutamine

• School: University of Sydney
• Department: Exercise and Sport Science
• Course: EXSS2028
• Professor: Kieron Rooney

Document Summary

Fat comes through fat transporter on cell membrane. Indicators that the cell is working harder than usual = amp, h+ & pi accumulation: nh4 accumulation in the cell stimulates metabolic pathways to release more fuel to make it easier to do the work. & glycerol [lipolysis: acc2 turned off when ampk adds pi to it; used in citrate-malate shuttle citrate in cytosol. Acetyl coa & oaa acc converts acetyl coa into malonyl coa malonyl coa does not accumulate in the skeletal muscle with acc2 when amp levels are high [fat transport. Metabolic signals of increasing energy demand: lecture 5. Rate of pfk activity (& glycolysis) is linked to energy status and need of the cell. It binds to the allosteric site on pfk to ensure it is closed: h+ makes other inhibitors bind tightly (together) to also act as an inhibitor. Ammonium: glutamate + ammonium = glutamine, ammonium amp deamination, glutamine indicates cell is under stress, alanine indicates glycolysis.