BIOL1007 Lecture Notes - Lecture 2: Transfer Rna, Hydrolysis, Central Dogma Of Molecular Biology
19 May 2018
School
Department
Course
Professor
Explore the properties of information and how these features apply
to the molecular basis of genetic information
Stable - resistant to attack from compounds inside the cell
○
Corruption-free - can't be modified
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Protected
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backed up - for repair
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Stored
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Accessed (easily)
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Retrieved (quickly)
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Transferred (copied accurately)
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Read (decoded easily and selectively)
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Used (appropriately)
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Information needs to be
Screen clipping taken: 12/08/2017 3:50 PM
Example - information management in our body
Information is opposite of entropy, all about ORDER (entropy is disorder)
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Increasing entropy is inevitable outcome of 2nd law of thermodynamics
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Info is working AGAINST entropy, ENERGY required to maintain order
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Nature of information
Carbon based IT
Example
equivalent
The
genome
(DNA)
Long term
memory
The
tRNA - adapter,
Short term
L2 - information in cells
Saturday, 12 August 2017
3:35 PM
Mod 1 Information transfer Page 1
Document Summary
Explore the properties of information and how these features apply to the molecular basis of genetic information. Stable - resistant to attack from compounds inside the cell. Information is opposite of entropy, all about order (entropy is disorder) Increasing entropy is inevitable outcome of 2nd law of thermodynamics. Info is working against entropy, energy required to maintain order. The doing molecules, the actions trna - adapter, 15-16% rrna - where we make proteins, creates environment where we make the peptide bond, about. 80% of the weight mrna - 1-2%, very unstable. Small nuclear rna - help splice out the stuff that"s not coding. Micro rna - help regulate rate of translation of different sequences. Transcription factors enable you to switch genes on/off. Summarise the flow of genetic information from dna to rna to protein in terms of the central dogma. Can have reverse transcription from rna to dna. Transcription - copying, can be done outside cell.
