ANAT2010 Lecture Notes - Lecture 8: Drunken Sailor, Motor Learning, Dysmetria
Document Summary
Lecture 8 motor pathways ii (skilled movement: additional circuitry required for voluntary and skilled movements (basal ganglia, cerebellum, movement disorders (cerebellar ataxia, summary of skilled movement. Cortex: projects to basal ganglia, receives info back from basal ganglia, forms a loop". Basal ganglia: projects to ventral lateral (vlo) thalamic nucleus, provides major input to sma (area 6, function of the loop: selection & initiation of willed movements. Input nuclei: striatum (caudate nucleus, putamen: external globus pallidus (gpe, subthalamic nucleus (stn, substantia nigra pars compacta (snpc, output nuclei (internal globus pallidus (gpi) & substantia nigra pars reticulata (snpr)) Consists of a loop: cortex striatum globus pallidus/substantia nigra thalamus back to same cortical region. Direct pathway: selection & initiation of willed movements. In direct pathway: gabaergic putamen neurons inhibit the basal ganglia output nuclei [internal globus pallidus (gpi) & substantia nigra pars reticulate (snpr)] Inhibition of the vlo decreases excitatory output projecting to sma & prevents movement.
