NUTR3201 Lecture Notes - Lecture 15: Diabetes Mellitus Type 2, Mutation, Pharmacokinetics
Document Summary
2 roles of pufa (omega 3 and 6, what about 9?) As ligand activating ppar (tf) -> rxr attach -> bind to ppre -> promote gene expression (nutrigenomic effect) As precursor for eicosanoids; elongation la -> aa -> eicosanoids as pro in ammatory and ala -> epa -> dha -> eicosanoids as anti in ammatory response/effect (conversion) Snp affect how much and how gene being expressed. Epigenetic markers add and remove dynamically though (methylation demethylation acetylation deacetylation?) We inherited 1 allele from mum 1 allele from dad. Heritability can be modi ed vs inheritability cannot be modi ed and have no environment in uence. Mutation is any abnormal change in dna for example changing the whole sequence vs snp is commonly found in population. We want to prevent snps to prevent onset of chronic disease. Ageing: nrf2; shortening of telomere as we expose to more pro-oxidant; in ammation reducing cell to cell communication; stem cell exhaustion;
