NEUR3002 Lecture Notes - Lecture 5: Kainic Acid, Unimodality, Brainstem
The Learning and Fearful Brain: Memory
Systems
1. Multiple Memory Systems
2. Memories and Different Durations
Iconic memory (Sensory buffer) ms
Short-term memory (declarative, e.g. phone number) sec
Intermediate long-term memory (e.g. where you parked this AM) min to hour
Long-term memory days to indefinite
find more resources at oneclass.com
find more resources at oneclass.com
3. Centralised vs Distributed Memories
4. H.M.
Henry Molaison removed hippocampus and amygdala
Cure severe epilepsy
Anterograde amnesia inability to form memories after amnesia onset
Time limited, graded retrograde amnesia loss of memories formed 11 years before onset
Lost ability to consolidate memories
MTL/hippocampus critical for learning & memory
Hippocampus involved in making long-term memories
Long-term memories stored outside hippocampus @ neocortex
HM could learn new motor skills (mirror-tracing task) fewer errors during performance each day ∴
hippocampus not crucial
find more resources at oneclass.com
find more resources at oneclass.com
5. Alzheimer’s Disease
Formation of amyloid plaques and neurofibrillary tangles
Shrinking cerebral cortex, hippocampus, entorhinal cortex
6. Formation of Memories
Hippocampus sends and receives info to and from unimodal/ polymodal association areas
Information from different modalities converge on EC and hippocampus
7. Hippocampus and Spatial Learning
7.1. Morris water maze
- Rats placed in milky water with submerged platform
- Rats don’t like to swim
- Quickly learn location of platform and swim to it forms place cells
- Lesioned rats don’t remember location but eventually find it
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Systems: multiple memory systems, memories and different durations. Short-term memory (declarative, e. g. phone number) sec. Intermediate long-term memory (e. g. where you parked this am) min to hour. Long-term memory days to indefinite: centralised vs. Anterograde amnesia inability to form memories after amnesia onset. Time limited, graded retrograde amnesia loss of memories formed 11 years before onset. Hm could learn new motor skills (mirror-tracing task) fewer errors during performance each day hippocampus not crucial: alzheimer"s disease. Shrinking cerebral cortex, hippocampus, entorhinal cortex: formation of memories. Hippocampus sends and receives info to and from unimodal/ polymodal association areas. Information from different modalities converge on ec and hippocampus: hippocampus and spatial learning. Rats placed in milky water with submerged platform. Quickly learn location of platform and swim to it forms place cells. Lesioned rats don"t remember location but eventually find it. Group of place cells (place field) fire when moving through specific location in an environment.
