MEDI7212 Lecture Notes - Lecture 98: Neoplasm, Otitis Media, Tlr3
Document Summary
Primary: genetic abnormality, typically manifests during infancy or childhood, humoral immunity defect, cellular immunity defect, combined humoral and cellular immunity defect, phagocytic cell defect, complement defect. Immunosuppressive treatments (cytotoxic therapy, bone marrow ablate before transplant, radiation therapy) Less common manifestations: severe viral infection (eg hsv or vzv), cns problems (eg chronic encephalitis, delayed development, seizure disorder, differentials, repeated infection exposure at day care or school (infants, children) Inadequate antibiotic treatment duration, resistant organisms, other disorders that predispose to infection (eg congenital heart defect, allergic rhinitis, ureteral or urethral stenosis, immotile cilia syndrome, asthma, cf, severe dermatitis) Frequent use of antibiotics may mask common sx and signs. Cellular immunodeficiency (t cell: patient is prone to viral, fungal and protozoal infections; ig production can be, wiskott-aldrich syndrome (was) Clinical presentation: triad - microthrombocytopenia, eczema, recurrent infections (do not need all 3 present for clinical diagnosis, 40-70% patients develop autoimmune disease.
