MEDI7212 Lecture Notes - Lecture 96: Plasma Cell, Mycobacterium, Clostridium Tetani
Document Summary
Specific infection response: overview of protective sites, antiviral response. It will only protect against an extracellular virus previously encountered. Interferons: many cell types release in response to viral infection (dsrna is powerful inducer, non-specific action against all viruses. Ifna or ifnb are produced early in viral infection -> bind to receptors -> resist viral replication in cells, increase mhc class i expression & activate nks. Target tissue: main defences, antibody, neutralization, aid complement-mediated lysis of infected cell/ enveloped virus, initiate adcc, complement, nk cells. Interferon: cd16+, cd56+, no tcr or bcr (ig) Response type of immunity that is most effective depends on cell wall & pathogenicity: cell wall structure (gram +ve or -ve) Lipid bilayer of gram -ve bacteria makes them more susceptible to lysis by complement and cytotoxic cells: complement defects -> neisseria and other gram -ve infections predominate, waxy cells wall of mycobacteria makes them extremely resistant to degradation.
