MEDI7212 Lecture Notes - Lecture 95: Asthma, Thymus, Helminths
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Innate: natural immunity, present from birth, ag independent, non-specific, no immunological memory, rapid immune response (min-hr) after aggression. Second line - enzymes, complement system, acute phase proteins, phagocytic & nk cells with. Adaptive acquired immunity: ag dependent, specific, retain immunologic memory. Specialised apcs express mhc class ii (hla dp/dq/dr) carrying exogenous extracellular foreign ag peptides: antibody/ ig, ag-binding sites on ig will recognise 3d structures (unlike tcrs that only bind short peptide segments without tertiary structures) Somatic recombination (rag1 and rag2 induced) of gene segments within b lymphocytes allows for the vast majority of ig. Predominant ig in serum with longest half life (3wks) Predominant ig secreted at mucous membrane surfaces for immunity. Early in immune responses to provide rapid adaptive immunity. Most efficient at activating complement & important for opsonization. Bind to fcrei receptors on mast cells and basophils. Inhaled or ingested ag activate cells in malt.
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