MEDI7212 Lecture Notes - Lecture 93: Hypotension, Sputum Culture, Enterococcus Faecium
Document Summary
Mechanism of action: remember vancomycin (gram +ve) and gentamycin (gram -ve, most important concept is selective toxicity (selective inhibition of growth of microorganism without host damage) Bacteriostatic drug: kills bacteria, use in certain infections that are. Inhibit bacterial growth: no killing of bacteria, thus may grow again upon immediately life-threatening, patients whose pml count is below. 500/ul, and endocarditis (phagocytosis is limited by fibrinous network of vegetations: 4 major sites for antibiotic action drug withdrawal. Inhibit cell wall synthesis: antibiotic inhibition of crosslinking peptidoglycans, penicillins, cephalosporins, imipenem, aztreonam, vancomycin, antibiotic inhibition of steps in peptidoglycan synthesis, cycloserine, bacitracin, antifungal inhibition of b-glucan synthesis, caspofungin or micafungin. Inhibit protein synthesis: action on 50s ribosomal subunit, chloramphenicol, erythromycin, clindamycin, linezolid. Inhibit nucleic acid synthesis: action on 30s ribosomal subunit, tetracyclines, aminoglycosides. Alter cell membrane function: antibacterial activity, polymyxin, daptomycin, antifungal activity, amphotericin b, nystatin, terbinafine, azoles, host factors.
