MEDI7212 Lecture Notes - Lecture 32: Hypercalcaemia, Hypovolemia, Hypothyroidism
Document Summary
Introduction: tdm is the measurement of plasma/ blood concentration of a particular drug to optimise a patient"s dosage regimen and therapeutic outcomes via maintaining drug concentration within a target therapeutic window. Indications: after initiating treatment or adjusting dose. Start or stop a potentially interacting drug: change in patient"s physiology (pregnancy, renal or hepatic impairment, treatment is failing, non-compliance is suspected, confirm abstinence, assess for drug toxicity or suspected overdose, assist diagnosis. Drug criteria for monitoring: marked pharmacokinetic variability (inter- or intra- individual, narrow therapeutic index, evidence-based therapeutic range, defined concentration-effect relationship, no appropriate direct measure of desired therapeutic effect. Serious consequences (seizures, transplant rejection) if there is therapeutic failure. Important information: patient characteristics (age, gender, ethnicity, concomitant disease, concomitant medications. Indications for monitoring: time of blood collection, dosage regimen (dose, dose form, time of administration, duration of therapy, therapeutic range and pharmacokinetics of drug.
