BIOM3014 Lecture Notes - Lecture 1: Interleukin 22, Cytokine Receptor, Interleukin 5
Document Summary
Ifst with crystal structure solved (even ligand bound: change in structure is involved in causing activation of receptor, cytokine receptors summary. [roduce igf-1 major role in controlling growth: overlapping effects with gh (lot of effects on metabolim, growth hormone binds receptor activates jaks activates stat, forms complex, goes to numcleus, gene transcription and new gene expression. Jaks are bound to a receptor: stat come up bind form complex and goes to nucleus, there are 4 jaks. Jak 2 used by a wide rane particularly homodimerc. Leads to activation: fret measurements, tags protein with fluorescent proteins, as they come closer together the fonor will florues. Information on how closely proteins are associated: ratio. Il-6 signalling: on gp130, seems to be no jak bound, therefore all signalling will go trhough dimer of gp130, signalling mechanism can get more com plicatef, trasmision of signal seems to parallel ghr. Il6r and gp130 expressed on the membrane of the cell.
