BIOM2071 Lecture Notes - Lecture 18: Iron-Deficiency Anemia, Hemolytic Anemia, Pernicious Anemia
Document Summary
B vitamins required for dna synthesis b12 and folate (b9) Want of blood": blood loss (haemorrhagic anaemia): acute/chronic (haemorrhoids/bleeding ulcer, rbc deficiency: Purposive injection of non-food items (eg. earth, clay, dirt, ice/freezer frost. Association between ice ingestion and iron deficiency anaemia. Natural/healthy fall in haemoglobin = physiologic/dilutional anaemia of pregnancy. Greater expansion of plasma volume (50%) than rbc volume (25%) Haematocrit = ratio of rbc to total blood volume. Lowest during late 2nd early 3rd trimester: 1st trimester: hb <11g/dl or hct <33, after: hb <10. 5g/dl or hct < 32, severe: hb 8. 5g/dl. Common cause: iron deficiency or acute blood loss. Risks: preterm birth, pprom, infection, foetal growth restriction. Symptoms: fatigue, breathlessness, palpitations, difficulty concentrating, lower intellectual/productive capacity. Iron screening (standard: mean corpuscular/cell volume (mcv) size of rbc (micro/normo/macrocytic, mixed nutritional deficiencies can lead to normocytic anaemia (folate/iron, red cell distribution width (rdw): caused by nutritional deficiencies.
