PSYC3241 Lecture Notes - Lecture 3: Protein Synthesis Inhibitor, Anisomycin, Memory Consolidation
30 May 2019
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Document Summary
Temporal gradient is the main empirical basis for the concept of memory consolidation. Requires functional or structural changes in the brain. Remaud infused protein synthesis inhibitor into ca3 region of hippocampus. Time-dependently impairs memory of context fear in mice. Some mice injected with protein synthesis inhibitor after immediately training- c. Other mince injected with vehicle after immediately training. If mice are injected 30 minutes before test, there is no effect- the memory has al already occurred. According to consolidation theory, injection of protein synthesis inhibitory 24hrs after. 24 hours later, cs presented alone and high or low dose anisomycin injected into. Rats given high dose anisomycin freeze less- memory is retrived and then recons. Follow up experiment disproved these alternatives about anisomycins affects. High does of anusomycin had no effect on freezing when given 24 hours after cs. Third experiement, used a temporal gradient of anisomycin injection. Fourth experiment, they waited 2 weeks before injecting anisomycin.
