BVB212 Lecture Notes - Lecture 7: Leukotriene, Salbutamol, Degranulation

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11 Aug 2018

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Objectives: understand the components of the respiratory system, understand the physiology of respiration, understand the factors that control inhalation and exhalation. Functions of the respiratory system: gas exchange, thermoregulation, ph balance, vocalisation, olfaction, humidification and warming of inhaled air, water loss (in dogs, protection of respiratory surfaces (mucous production) Divided into: external respiration, exchange of o2 and co2 between atmosphere and tissues, exchange systems: o2 and co2 diffuse in/out of blood from/to air sacs, transported to/from. Involves the respiratory and circulatory systems tissues by blood and then diffuse in/out of tissues: cellular respiration, mitochondria use o2 to produce atp and produce co2 as a waste product. Pulmonary circulation: outflow from right ventricle (deoxygenated, alveolar capillaries for gas exchange, blood can be diverted preferentially to fully inflated lung, oxygenated blood flows back to the left atrium. Smooth muscle in pulmonary arteriole walls regulate blood flow. Inspiration: active process - enlarge volume of lungs, decrease pressure in lungs.

Related Questions

1. Which of the following are considered blood vessels within the cardiovascular system? (Select all that apply.)

Veins

Arteries \

Epithelial tissue

Capillaries

Epidermis

2. The middle muscle layer found in the walls of the heart is the __________.

Myocardium

Epicardium

Endocardium

Aorta

3. Blood is transported throughout the body via ___________.

Veins
Arteries

Capillaries

All of the above

4. The right atrium receives blood from all parts of the body except the ______________.

Abdominal cavity

Lungs

Dorsal cavity

Cranium

5. Blood carries which of the following?

Oxygen and cellular waste

Oxygen, nutrients, hormones, enzymes, and cellular waste

Nutrients, hormones, enzymes

Oxygen, nutrients, enzymes

6. Vocal chords are found in the ____________.

Bronchus

Trachea

Larynx and Pharynx

Nasal cavity

7. The trachea is mostly lined by ________________.

Alveoli

Ciliated

mucous membrane

Lung capillaries
Vocal chords

8. Excess CO2 from the body is __________________.

Stored in the pancreas

Digested by cells

Excreted by the respiration process

Used to make ATP

9. CO2 from the body is released into the lungs via _________________.

Ciliated mucous membrane

Alveolar air

Nasal cavity

Bronchial tree

10. The principal function(s) of gas exchange is ____________________.

To supply cells with oxygen

To remove CO2 from the body

Both A and B

Neither of the above

One of the most common chronic conditions affecting the respiratory system is asthma. Asthma is a condition characterized by inflammation of the airways. When an asthma attack is triggered, the airways become even more inflamed and can restrict breathing. Common symptoms during an asthma attacks include coughing, wheezing, tightness in the chest and shortness of breath. Severe asthma attacks can be fatal. People with a family history of asthma are more likely to have the condition. While there is no cure for asthma, proper medical care and a management plan can help to maintain quality of life for people living with asthma. There are different types of asthma, each with their own triggers and management plans. Type Description Exercise-induced Bronchoconstriction (EIB), or Exercise-induced Asthma (EIA) Some people only experience asthma symptoms during exercise. Exercise-induced asthma causes the narrowing of airways during exercise, which restricts the flow of air to and from the lungs. Cold, dry air tends to exacerbate symptoms, while warm, humid air may reduce symptoms. People with exercise-induced asthma should work with their doctor to create a management plan that still allows them to exercise while keeping their symptoms under control. Allergic Asthma Allergic asthma is the most common form of asthma. It is triggered by inhaling allergen particulates, such as dust mites, pollen, pet dander, or mold. The bodyâs reaction to the allergens causes inflammation that results in coughing, wheezing, and other symptoms of asthma. Occupational Asthma Occupational asthma is caused by the frequent inhalation (breathing) of gases, fumes, dust, or other harmful substances in the workplace. Employees working in the chemical or petroleum industries are frequently exposed to chemicals such as Sulphur dioxide or hydrochloric acid, and may develop occupational asthma after prolonged exposure. Childhood Asthma Childhood asthma is usually developed before age 5. It is a condition that affects millions of children. It is vital that childhood asthma is properly controlled to prevent damage to the developing lungs Risk factors: â¢ Allergies â¢ Family history â¢ Frequent respiratory infections â¢ Low birth-weight â¢ Second-hand smoke â¢ Residing in a low-income, urban environment

Asthma symptoms that are triggered by exposure to pollen, pet dander, mold, or dust mites is indicative of which of the following types of asthma:

Occupational asthma

Childhood asthma

Allergic asthma

Exercise-induced asthma

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True of False: Freshwater environments have a higher concentration of oxygen than saltwater environments.

QUESTION 2 If the difference in partial pressure of gas on either side of the barrier to diffusion is 0, which of these events will occur?

The area for gas exchange will increase to accommodate this similarity.

The constant for diffusion will decrease.

The rate of diffusion will be 0.

The distance thickness of the barrier to diffusion will also be 0.

QUESTION 3 On the x-axis of the oxygenâhemoglobin equilibrium curve is the partial pressure of oxygen in tissues. Which type of blood is most likely to be represented by the right-hand side of the axis? (Hint: the oxygen-hemoglobin equilibrium curve is figure 45.14 in your book on pg 913)

blood found in the left ventricle

blood found in the right atrium

blood found in the superior vena cava

blood found in the inferior vena cava

QUESTION 4 Which of these is an example of pulmonary circulation?

Blood is pumped from the right ventricle to the lungs.

Blood is pumped from the left ventricle to the aorta.

Blood is pumped from the aorta to the cardiac vein.

Blood is pumped from the inferior vena cava to the right atrium.

QUESTION 5 O2 will diffuse from blood to tissue faster in response to which of the following conditions?

an increase in the PO2 of the tissue

a decrease in the PO2 of the tissue

an increase in the thickness of the capillary wall

a decrease in the surface area of the capillary

QUESTION 6 Which of the following promotes oxygen release from hemoglobin?

a decrease in temperature

a decrease in carbon dioxide levels

a decrease in pH

a decrease in carbonic anhydrase

QUESTION 7 How does the medulla oblongata sense the amount of carbon dioxide in the blood?

A. Carbonic anhydrase produced by cells performing cellular respiration is exported and travels though the blood, and binds to a receptor on the medullary respiratory center, which causes a signal amplification resulting in a change in gene expression which results in the production of proteins that will cause the diaphragm to contract

B. CO2 produced by cells performing cellular respiration reacts with blood plasma for form an acid, which increases the pH of the blood, which causes the medullary respiratory center to contract the diaphragm

C. CO2 produced by cells performing cellular respiration reacts with blood plasma for form an acid, which decreases the pH of the blood, which causes the medullary respiratory center to contract the diaphragm

D. A and B

E. A and C

QUESTION 8 Which of the following parts of the lung are considered "dead space"? A. The alveoli B. The trachea C. The bronchi D. B and C E. All of the above

QUESTION 9 Which of the following blood vessels have the thinnest walls?

arteries

arterioles

capillaries

venules

veins

QUESTION 10 How does the interstitial fluid return to the bloodstream?

A. Interstitial fluid flows into the capillary where the osmotic pressure driving fluid into the bloodstream is greater than the blood pressure driving fluid out of the blood

B. Interstitial fluid flows into the capillary where the blood pressure driving fluid into the bloodstream is greater than the osmotic pressure driving fluid out of the blood

C. Interstitial fluid leaves the tissue via lymphatic ducts and travels through the lymphatic system, which returns the fluid to the veins. D. A and C

E. B and C

QUESTION 11 True or False: When an electrocardiogram (EKG or ECG) shows a flat line (aka asystole), medical personnel will restart the heart using a defibrillator.

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The human body is truly remarkable and is designed tofunction effectively. Organs are important structures composed ofdifferent tissues that facilitate specific functions within thebody. Organs function as part of an integrated group of structuresknown as organ systems. These organ systems form the organizationalunits that are responsible for crucial processes necessary forsustaining life.

Examples of organ systems include but are not limitedto the cardiovascular system, the digestive system, themusculoskeletal system, the nervous system, the excretory system,the endocrine system and the respiratory system. Even organ systemsdo not function alone. These systems work together, interactingwith other organs in a functional network that keeps the body inbalance. (Look up the term homeostasis in your text.) When homeostasis orthe normal functioning of organ systems is disrupted, disease maydevelop causing injury to the body, or even death. In thisassignment, you will explore organ systems, as well as associateddiseases or malfunctions.

Assignment details:

Take a look at the following casestudies that detail an outcome associated with a disease/organmalfunction. Select onestudy to investigate further for yourassignment.

Critically evaluate the information provided andcorrelate it with the organ systems that are affected in thescenario. Use the information that you have gathered to answer theassignment questions that follow the case study. For assistancewith your assignment, please use your text, the AIU Library, Webresources, and course materials.

Case Study 1:

Atherosclerosis isnarrowing of arteries caused by the accumulation of fatty depositson the arterial walls.

On June 22, 2002 the St. Louis Cardinals werepreparing for their upcoming baseball game against the Chicagocubs. Concern arose when their prized pitcher, 33-year old DarrylKile did not show up for practice. Soon after, he was found stillin his hotel room where he had suddenly died in his sleep (New YorkTimes, 2002). It was discovered that the cause of death was relatedto three of his coronary arteries being 80-90% blocked as a resultof atherosclerosis (New York Times, 2002), which ultimately causedhim to undergo a heart attack.

Answer the following assignmentquestions:

Why would atherosclerosis result in a heart attack?Provide a brief explanation based on how the heart functions.
How are arteries different from veins andcapillaries? Describe the functions of both arteries andveins.
Vertebrates and some invertebrates have a closedcirculatory system. Explain the advantage of having a closedcirculatory system over an open circulatory system?
Briefly explain how the lymphatic system isassociated with the circulatory system?
Describe one disease that affects the lymphaticvessels similarly to the way that atherosclerosis affects thearteries?

Case Study 2:

Cigarette smoking remainsthe leading preventable cause of death in the United States,causing an estimated 438,000 deaths - or about 1 out of every 5 -each year (National Cancer Institute, 2008).

Mr. Amos is now 57 years old and has been smoking forthe past 30 years of his life. A recent doctor's visit reveals thatMr. Amos has stage 3 lung cancer, characterized by his symptoms ofnagging chest pain, fatigue, coughing up blood, substantial weightloss, and increased carbon dioxide levels in his blood. The doctorinformed Mr. Amos that had he quit his smoking habit several yearsago, he would have reduced his risk for developing lung cancerlater in life. Mr. Amos immediately begins treatment for the lungcancer that has metastasized to his lymph nodes.

Answer the following assignmentquestions:

What main components in cigarettes affect therespiratory system? Explain their effects on specific organs, cellsand/or processes in the respiratory system.
There are alternate mechanisms of transportingcarbon dioxide (CO2) and oxygen (O2 ) in the blood. Explain howsmoking might lead to increased levels of carbon dioxide in theblood.
Can smoking affect other organ systems of the body?Give specific examples and briefly explain your answer.
How can you correlate cellular respiration with therespiratory system?
Does smokeless tobacco present a reduced risk forlung cancer and other smoking associated diseases? Provide evidencefor your answer.

Case Study 3:

Gigantism is abnormallylarge growth during childhood caused by excess growth hormonesecreted by the anterior pituitary gland.

Robert Wadlow, born on February 22, 1918, weighed anormal eight pounds, six ounces. However, by the time Robertreached the age of six months old, he weighed 30 pounds (Hamilton,1993). Within only a year, his weight rose to 62 pounds, more thandouble the normal weight of a baby at 18 months. Aside from hisweight, Robert continued to grow at an astounding rate, reachingsix feet, two inches and 195 pounds by the time he was eight yearsold. Robert's unique size was attributed to an over activepituitary gland, which produced much higher than normal levels ofgrowth hormone. At the time of his death in July 1940 at the age of22, Robert had reached a height of 8 feet 11.1 inches and weighed485 pounds (Hamilton, 1993).

Answer the following assignmentquestions:

How does growth hormone regulate various bodyfunctions in adults, and what could cause the excess secretion ofgrowth hormone?
Discuss the relationship between growth hormone andinsulin, and are there complications associated with theirinteraction?
Why is gigantism usually more difficult to treatthan dwarfism?
Give examples of two other hormones secreted by thepituitary, and briefly describe how they specifically affect otherorgan systems of the body?
Some athletes have resorted to the illegal use ofanabolic steroids to increase strength and muscle size. How areanabolic steroids different from growth hormone? Briefly explainyour answer.

References

Hamilton, S. (1993). Looking backand up: At Robert Pershing Wadlow, the gentle giant. Alton,IL: Alton Museum of History and Art.

National Cancer Institute. (2008). Tobacco statistics snapshot. Retrieved fromhttp://www.cancer.gov/cancertopics/tobacco/statisticssnapshot#0_references

The New York Times. (2002, July 17). Baseball: Coroner verifies the cause of Kile's death asnatural. Retrieved fromhttp://www.nytimes.com/2002/07/17/sports/baseball-coroner-verifies-the-cause-of-kile-s-death-as-natural.html?ref=darryl_kile

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BVB212 Lecture Notes - Lecture 7: Leukotriene, Salbutamol, Degranulation

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