BVB212 Lecture Notes - Lecture 6: Encainide, Cardiac Glycoside, Heart Block
Document Summary
The heart functions to deliver drugs from the central compartment (plasma) to the tissues: to site of action, organs gets variable portions of co, drug action affected by co. What happens if it is a cv drug. Increased delivery to heart: decreased delivery to heart, effects of metabolism and clearance. Striated: 1-2 nuclei, high mitochondrial density (atp, calcium important for contraction, non-cardiomyocytes, pacemaker cells, cardiac fibroblasts, vasculature - smooth muscle cells and endothelial cells, extracellular space, nerves. Cardiovascular pharmacology: drugs that affect cardiac myocytes, anti-dysrhythmic drugs. Inotropes (cardiac glycosides: autonomic neurotransmitters, calcium antagonists. Classified according to: location (atrial, ventricular, rate (tachy = increased, brady = decreased) Caused by: delayed after-depolarisation, re-entry, ectopic pacemaker activity, heart block. Pathology underlying dysrhythmias (don"t need to know this in depth) Anti-dysrhythmic drugs: not usually used in life-threatening dysrhythmias (don"t need to remember these classes ffs)
