LQB292 Lecture 11: Autoimmunity
7 Nov 2018
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Lqb292 principles of infection and immunity autoimmunity. Autoimmunity the system of immune responses of an organism against its own healthy cells and tissues. A(cid:374)y disease that results fro(cid:373) a(cid:374) autoi(cid:373)(cid:373)u(cid:374)e respo(cid:374)se is a(cid:374) (cid:862)autoi(cid:373)(cid:373)u(cid:374)e disease(cid:863) Results in chronic and lifelong conditions: autoimmunity is a combination of faulty genes and something in the environment acting as a trigger. Comparison of autoimmune disease organ specific vs non-organ specific (systemic autoimmune diseases: organ specific autoimmune diseases damage localised to a single organ or tissue. Example: type 1 diabetes (a chronic condition in which the pancreas produces little or no insulin) Example: systemic lupus erythematous (inflammatory disease where the immune system attacking its own tissues) Result of genetics and environment (sunshine, smoking, hormones, medication) Cell apoptosis results in apoptotic bodies and parts of the nucleus to be free. Susceptibility genes reduce clearance ca(cid:374)"t remove apoptotic bodies. Susceptibility genes mistake parts of the nucleus (dna, histones, proteins) and attack.
