LQB292 Lecture Notes - Lecture 5: Endothelium, Nasal Cavity, Monocyte
Document Summary
Structure: virus are small 20 - 350 nm. Icosohedral - spherical in appearance: have a clustered appearance, e. g. Unenveloped: rhinovirus - common cold, human papilloma-virus, e. g. enveloped viruses, hep b, hep c, measles. Influenza: all have the genome protected by capsid, genome + genome = nucleocapsid, rna or dna. Icosahedral or helical: lipid envelop or rigid capsomer or no envelop, classifications, genome dna or rna --> capsid shape --> envelop or no envelop --> genome architecture, genome architecture, transmission, contact, direct physical contact. Indirect contact - fomites, faecal-oral, droplets: common vehicles, air. Food: water, vectors, mechanical (e. g. rabid dog, biological (e. g. mosquitos) Iatrogenic (virus carried through blood transfusions: nosocomial (hospital acquired, zoonotic (animals, congenital (genetic - mother to fetus) Influenza: rna virus, enveloped virus (lipid bilayer, transmission, direct contact - sneezing, coughing. Invasion: respiratory tract: tropism: ha protein attaches to sialic acid on respiratory epithelial cells.
