PHYS30005 Lecture Notes - Lecture 13: Alternative Splicing, Costamere, Transmembrane Protein
25 Jul 2018
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Lecture 13 key functional proteins in skeletal muscle. Repeating units run between z discs along the length of the myofibril. Rib-like stru(cid:272)tures (cid:894)(cid:862)(cid:272)ostal(cid:863)(cid:895) o(cid:374) the surface of the sarcolemma. Costamere specialised sites of transmembrane complexes, occurring over the entire sarcolemma, where the transmission of force is concentrated. Stabilise sarcolemma during contraction especially during forced lengthening. Mechanical links between the sarcomeres within the muscle fibre and laminin in the ecm. Multimeric protein complexes (vinculin, talin, integrin and others) at the costamere are required for force transmission during contraction. Attach to z line of actin and cell membrane (integrin attaches to. When costameric complexes are disrupted, force transmission through the sarcolemma cannot occur. Two important complexes link the extracellular matrix to the actin cytoskeleton: dystrophin-glycoprotein complex (dgc, integrin-talin-vinculin complex. Multimeric protein complex that acts to link the basal lamina to the actin cytoskeleton in skeletal muscle fibres.
