PHYS30001 Lecture Notes - Lecture 32: Gestational Diabetes, Insulin Resistance, Vascular Resistance
Document Summary
Impact on maternal adaptations to pregnancy and influence on the development of the next generation. Programmed effects in adults born small are not limited to affect the first (directly exposed) generation but could be transmitted to subsequent generations; limited evidence (difficult to control all variables) Pregnancy is the greatest physiological challenge facing females. Plasma volume and cardiac output: glomerular filtration rate, insulin synthesis & secretion, insulin resistance, peripheral & renal, uterine vascular resistance. At risk of developing hypertension, glucose intolerance & gestational diabetes in pregnancy. Mate females born small with normal males, examine pregnancy adaptions and look at next generation. F1 females born small who become pregnant have the same: Uterine vascular function as control f1 females during late pregnancy. Hence: our experimental model is not confounded by these factors known to complicate. E18 (late gestation) maternal gtt glucose tolerance test - adverse pregnancy adaptation.
