PHYS30001 Lecture 30: 30 Role of placenta in DOHAD A
Document Summary
The placenta is the central regulator of pregnancy outcomes. Hormone production: signals from placenta trigger development of organs. No atp required, down concentration gradient i. e. glucose through glut transporters e. g. No atp required, down concentration gradient i. e. glucose through glut transporters e. g. glut1/3. Atp required, cotransporters e. g. system a amino acid transporters. Atp required, cotransporters e. g. system a amino acid transporters i. e. amino acids, folate, micronutrients. Vesicular transport large molecules captured by microvilli i. e. immunoglobulins. Gradient of glucocorticoids from mother to fetus, with greater levels in the mother. Rather than blocking their passage, the placenta metabolises them. 11 -hsd2 (hsd11b2 gene) at levels far higher than any other tissue, to convert active glucocorticoids (cortisol) into inactive metabolites (cortisone) - prevents gc from reaching the fetus. Placenta must modulate maternal immune system to prevent rejection (fetus is a foreign object) Secretes neurokinin b binds phosphocholines, which parasites use to.
