PHYS30001 Lecture 27: 27 Developmental Origins of Renal Disease A
Document Summary
Kidney: adults who were born small are susceptible to: Human and animal models have shown a decreased nephron number in association with high blood pressure. Nephrogenesis continues postnatally in rat - modulating the environment could highlight ways to reverse nephron deficit. A human born at full term will have full complement of nephrons - similar in sheep but sheep have very different placenta (limitation of model) decreased nephron endowment associated with increased blood pressure. Cross-fostering to define critical periods of nephron development & programming of increased blood pressure. Increase in gfr/nephron ratio > damage to glomeruli (glomerulosclerosis) > more na in blood > increase bp. Glomerular number by birth weight adjusted for age, sex and race. Born small > higher chance of fewer glomeruli > increase risk of glomerular damage > increased risk high bp. Macrosomic (large) babies: having too many glomeruli is also not good. Renin angiotensin system (ras) - adults who were born small are susceptible to:
