PHYS30001 Lecture Notes - Lecture 29: Ureteric Bud, Glial Cell Line-Derived Neurotrophic Factor, Bone Morphogenetic Protein 4
Document Summary
Gdnf expressed in mm binds cret to induce invasion of mm. Myriad of other factors interact with gdnf: external factors that inhibit (robo2, slit2, Factors from mm (six1, wt1) regulate ub to upregulate cret. Bmps are members of the transforming growth factor b (tgf-b) family. Acts on activin like kinase (alk) cell surface receptors. Bmp-4 important for growth of ub and branching morphogenesis (negative regulator) Bmp4 expressed at border of wd early on. Other bmps expressed on pretubular aggregates or branching tip. Metanephric expression of bone morphogenetic protein (bmp) ligands. Bmp2-7 have been detected during different stages of metanephric development in distinct and overlapping domains. This schematic depicts the expression patterns following invasion of the metanephric mesenchyme by the ureteric bud at e11. 5 (a) and at a later developmental stage, e13. 5 (b). Gdnf and bmp-4 pathways in ureteric branching and branching morphogenesis.
