PHYS30001 Lecture Notes - Lecture 27: Kidney Disease, Angiotensin Ii Receptor Type 1, Adipose Tissue
Document Summary
Restricted males have (a) low nephron # at 6m (b) increased glom volume, glom hypertrophy: increased blood flow, structural damage (c) normal total glom volume. Adult female data 6 and 18 months. No bp at 18m low nephron number, no change in glomerular volume or total volume (protected) Cardio page 4 low nephron number, no change in glomerular volume or total volume (protected) glomerular hypertrophy at 18m. Plasma creatinine & renal mmp-9, tgf 1, col4 1. These males and females had the same mother. Nephron deficit is maintained but only males develop high bp. Wlodek uteroplacental insufficiency f1 phenotype - sex specific differences. This model uses a strain of rats that does not tend to develop obesity. Nephrogenesis & cardiomyocyte development continues postnatally in rat so can alter this. Studies highlight that early accelerated growth for babies born small is protective against disease; late accelerated growth is detrimental.
