PHYS30001 Lecture Notes - Lecture 19: Hypertrophy, Homeostasis, Angiotensin
Document Summary
Concentric: walls thicken, often at expense of capacity. Relative increase in heart size/mass: normalised by heart size/body size ratio. Hypertrophy (in 10% of general population, who have statistically bigger than average heart size): major independent risk factor for cv mortality (biggest risk factor after age) A compensatory strategy to: optimize thermodynamic state: to be more energy efficient reduce wall stress (load per cell): to reduce strain on each cell. Endurance: dynamic/isotonic/aerobic ie long distance running, swimming - lots of whole body movement, requires reduction of systemic resistance. Strength: static/isometric/anaerobic ie wrestling, weight lifting - extreme, rapid movement most athletics combine endurance & strength ie cycling, rowing involve alterations in complex central & peripheral mechanisms (structural, metabolic, regulatory): conditions the brain, sns, pns. Ie factors influencing left ventricular filling capacity" adjustment to training. Body size: ie perfusion volume requirement which may or may not be modified by training per se (body mass)
