MIIM20001 Lecture 26: Lecture 26

• School: University of Melbourne
• Department: Microbiology and Immunology
• Course: MIIM20001
• Professor: A/Prof Jason Mackenzie

Document Summary

Lecture 26- damage to the host: cause damage to the host. Botulinum toxin (clostridum botulinum: bacteria contaminate/colonise anaerobic environment (tinned food, able to produce spores that enable them to persist, even in highly oxygenated environments. It cleaves the snare proteins (syntaxin and snap 25) that are responsible for the fusion of the muscle cell with the vesicle containing. Single virulence factor f this bacterium: binds to heparin-binding epidermal growth factor precursor- specific for the surface of cell membranes, catalytic subunit is an adp-ribosyltransferase. The catalytic subunit is different to the botulin toxin (which is an enzymatic protease that cleaves the target protein), as the adp-ribosyltransferase catalyses the transfer of adp-ribose from nad onto elongation factor 2. The enzyme is taing adp-ribose and is transferring it onto elongation factor 2, inhibiting ef2 from helping the ribosomes make the protein- stops protein synthesis. The cells are unable to repair this fast enough.