BIOM30002 Lecture Notes - Lecture 36: Thioflavin, Neuroprotection, Oxidative Stress
12 Jun 2018
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Professor
L36 Therapeutics for ND diseases- interactive: pre-reading needed
Molecular/pathway targets
- Secretases (beta/gamma)
- Amyloid degrading enzymes
- Metals – chelators
- Amyloid beta (=Abeta)
- Tau
- Oxidative stress
- Inflammation
- Neuroprotection
See the other doc “ND drug list”
AD drugs have to be:
- Cross BBB
- Hit its molecular target
- Does not have harmful AE
- Can be easily administered – oral
Why have the major clinical trials failed?
- Mouse model is not accurate
- Not reflecting human pathology
- They were treating subjects that were too advanced along the disease pathway
- The drug target was no longer critical for the pathogenic/clinical phenotype
When do you treat?
- Depends on molecular target/pathology
- Hard to detect pre-clinical pathological changes
1. Use of biomarkers – CSF/brain/blood/urine
Physiological
Biochemical
Anatomical
2. PET imaging
PET = positron emission tomography
Thioflavin T (ThT)
Measuring amyloid in living people
