BIOM20001 Lecture 56: 56 Pathogen invasion and subversion of immune responses (summary) A
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56 pathogen invasion and subversion of immune responses (summary) Bacteria and viruses adhere to surfaces by adhesins on fimbriae, and other molecules that bind cell surfaces. Prevent binding (physical barriers): mucous, skin, salt, eg. peristalsis, cough reflex, blinking, commensals. Limit replication: bile salts, lactoferrin, lower ph - acidify environment. If the pathogen can evade these responses (fimbriae aid adhesion, capsules hide. For viruses, involves penetration of cell, uncoating, production of na and proteins by host cells. Bacteria may invade as part of the adhesion process. Pathogens that evade these responses go on to Due to toxins, cell death, the immune response. The linking of the innate response and adaptive immunity occurs for both intracellular and extracellular infection. Soluble and cell associated pattern recognition receptors recognise conserved molecular patterns on microbes. Ligation results in multiple functions, depending on the pamp-prr interaction, eg complement activation (inflammation, b cell responses)
