BIOM20001 Lecture Notes - Lecture 11: Endoplasmic Reticulum, Net Energy Gain, Pyruvate Dehydrogenase Complex
26 Jul 2018
School
Department
Course
Professor
Document Summary
No need to be able to draw the molecule, you just have to recognize them. The preparatory phase will use 2 atp, and payoff phase will produce 4 atp + 2 nadh. The net energy gain is 2atp and 2nadh per glucose equivalent in total to ~5 atp per glucose (because nadh store a lot of energy). Glycolysis proceeds up to 10 faster in cancer cells some chemotherapeutic agents available inhibit hexokinase (e. g. 2-deoxyglucose). The high glycolytic turnover in cancer cells is also used for diagnosis by injecting isotopically labelled glucose (18fdg 6-phospho-18fdg) followed by pet scanning. Your brain also light up because it performs high level of glycolysis. Your bladder light up because of the excess waste labelled glucose. Otto warburg proposed that most cancer cells produce energy by anaerobic glycolysis (even though oxygen is readily available) rather than by oxidation of pyruvate in the mitochondria (which is common to healthy cells).
