BIOL10005 Lecture Notes - Lecture 23: Allele Frequency, Genotype Frequency, Heterozygote Advantage
16 Oct 2018
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Genetics and evolution - lecture 23 - week 12. Example 2: 1 in 2500 people have cystic brosis which is caused by inheriting two copies on the recessive allele c. people with two copies of the c allele are healthy and cc are healthy carriers. Natural selection: selection: di erential survival and reproduction of individuals due to di erences in phenotype, fitness: the ability go a organism/genotype / allele to survive and reproduce. Monday, 15 october 2018: adaptation: evolutionary changes that result from selection, selection can change genotype frequencies and thus cause allele frequencies to change over time (ie: evolution) Stabilising selection: can produce new species average doesn"t change but there is less variation, extreme = good, average = bad. Malaria: there is a big heterozygous advantage in a region with malaria, population before selection, 1aa:2as: 1ss, population after selection, 3aa:10as: 1ss, heterozygotes are 14% tter than homozygotes. Frequency in g2 (renormalise by dividing by the population mean.
