BIOL10005 Lecture Notes - Lecture 10: Pyrimidine Dimer, Antennapedia, Aneuploidy
1 Oct 2018
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Genetics and evolution - lecture 10 - week 5. Induced mutations: di erent mutagens have di erent dna damaging e ects. Types of mutations: somatic changes are associated with sporadic (non inherited) cancers, germ line mutations can be inherited (reproductive tissue) such as the drosophila with either antennapedia or bithorax mutant (homeotic genes determine the di erentiation of body parts) : deletion or insertion of several base pairs, major alteration in chromosome number or structure, translocations are visible under a light microscope. Reciprocal translocation: rt between #9 and #22 chromosome forms an extra long chromosome 9, and the. Philadelphia chromosome (ph1) containing the fused abl-bcr gene: the bcr-c-abl fusion protein with increased tyrosine kinase activity which promotes cell division and leads to an over production of cells. Nonsense substitutions: premature termination of translation (chain termination, converts a codon for an amino acid into a termination codon, truncated protein often leads to reduced or no function.
