BIOL10003 Lecture Notes - Lecture 30: Small Nuclear Rna, Rna Splicing, Alternative Splicing

• School: University of Melbourne
• Department: Biology
• Course: BIOL10003
• Professor: All

Document Summary

Only occurs in eukaryotes, in the nucleus converts pre-mrna to mrna (cid:1005). Protects rna from degradation by nucleases, recognised by translation machinery (initiation) (cid:1006). (cid:1007)" polyadenylation. Up to 200 poly(a) tails added by poly(a) polymerase. Regenerates nucleus to cytoplasm transport: rna splicing cutting out introns. Removal of introns (intervening sequences) and joining of exons (expressed sequences) Alternative splicing allows different rnas and proteins to be made from the same gene, which may be more suited to different cells / tissues / organs. 3 base pairs = codon codes an amino acid. Aug = start codon; uaa, uag, uga = stop codons. Non-overlapping code that starts at a fixed place. The code is degenerate: more than one codon per amino acids. Codons that encode the same amino acids are synonymous codons. Wobble of the code describes codons where the last base is irrelevant. A site codon recognition between anticodon (aminoacyl-trna) and the codon (mrna) if it matches, it binds.