BIOL10003 Lecture Notes - Lecture 21: Testis Determining Factor, Seminiferous Tubule, Pseudoautosomal Region
12 Nov 2018
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Xxxx impaired cognitive development (mean iq 55) Xyy very tall, aggressive tendencies, impulsive, immature (2% of criminals) Up to 6 weeks in development humans have bipotential gonads (tdf. Dax 1 anti testis gene when activated. Sox 9 caused differentiation into seminiferous tubules when active. Sex reversal can occur with insertion/deletion of tdf. Females must get rid of wolffian ducts. Males must get rid of mullerian duct. 5-alpha reductase deficiency can result in ambiguous genitalia. Two types of 5 alpha reductase: type 1 is active in the adult liver, non-genital skin and some brain areas and type 2 is active in the testes. The rising testosterone levels at puberty sufficient levels of dht either by the action of. 5-alpha-reductase type 1 or through the expression of low levels of 5- alphareductase type 2 in the testes. X and y chromosomes have homologous regions (pseudoautosomal region):
