BIOL10003 Lecture Notes - Lecture 25: Sister Chromatids, Mendelian Inheritance, Centimorgan

• School: University of Melbourne
• Department: Biology
• Course: BIOL10003
• Professor: All

Document Summary

Lecture 25 - inheritance of more than one gene: autosomal linkage mapping 2 markers. Y linked: father to son transmission (e. g. tdf) X linked recessive: no father to son transmission, affected female has affected father and sons large pedigree with more affected males, unaffected parents have an unaffected child, more males affected than females. Autosomal recessive: if a generation is skipped and a female is affected (i. e. father is not), unaffected parents have an unaffected child. X linked dominant: father to all daughters; dominant traits do not suddenly appear in the pedigree - when a dominant trait is not passed on it disappears from pedigree. Autosomal dominant: father affected, not all daughters affected; do not suddenly appear in the pedigree - when a dominant trait is not passed on it disappears from pedigree. The phenotype is a result of multiple gene mutations complementation. Sometimes genes on the same chromosomes assort independently. Test cross a cross to a homozygous recessive individual.