BCMB30011 Lecture Notes - Lecture 22: Carbonic Anhydrase, Transamination, Alpha-Ketoglutaric Acid

• School: University of Melbourne
• Department: Biochemistry and Molecular Biology
• Course: BCMB30011
• Professor: professor watt

Document Summary

* ca(cid:374)cer cells ca(cid:374) store glycoge(cid:374) or (cid:373)ake glycoge(cid:374). Nor(cid:373)ally epithelial cells ca(cid:374)"t store glycoge(cid:374), and normal cancer cells have an epithelial origin e. g. colon cancer. * cancer cells express enzymes that are not normally expressed e. g. pkm2, normally a different form of pk is expressed. Differences in metabolic patterns of normal cells and cancer cells cancer cells are metabolic opportunists: * normal cell takes in glucose, glutamine and lipids and metabolise them. Glucose is normally metabolised by glycolysis & tca cycle & oxidative phosphorylation each glucose molecule gives 36 moles atp/mole glucose. * cancer cells stop the process of oxidative phosphorylation it"s slowed dow(cid:374) so it does(cid:374)"t go through tca cycle. Most of this glucose is channelled to the pentose phosphate pathway to make nadph. * the other source of carbon backbone is glutamine so cancer cells take up a lot of glutamine. They also channel glucose-6-phosphate into the pentose phosphate pathway.