PATH1001 Lecture 13: Renal Pathophysiology
Document Summary
Higher osmolality in the interstitial fluid the deeper in the kidney. Kidney function: excretion, regulation of blood volume and pressure, regulation of blood solute concentration, regulation of ph levels of the extracellular fluid, regulation of red blood cell synthesis, removal of waste products. Several layers surround them: renal capsule-layer of fibrous connective tissue, layer of adipose tissue, renal fascia-layer of connective tissue, final layer of adipose tissue. 2 capillary networks as they need a very good blood supply. The process of non selectively forcing small molecules and water out of the blood into the. Allows for: small blood components to move across. Capillary endothelial layer: contains many pores (fenestrations) allow for molecules to leave. Basement membrane: has spaces between fibres (wholes) for exit. Epithelial layer podocyte:has foot processes creating filtration slits damage to any could decrease filtration. Glomerular filtration pressure due to difference in arteriole size. 2 inward pressure- allowing for substances to be moved out.
