BCCB2003 Lecture Notes - Lecture 6: Enzyme Kinetics, Endergonic Reaction, Glucokinase
Document Summary
What are enzymes: catalysts in biological systems. Examples: copper, potassium, magnesium, manganese, organic molecules: Mostly derived from vitamins: prosthetic group, holoenzyme versus apoenzyme: Classification of enzymes: classified by what is catalyses and type of catalysed reaction the enzyme is involved in, classes, 1: oxidoreductases, 2: transferases, 3: hydrolases, 4: lysases, 5: isomerases, 6: ligases. How enzymes function: the active site is lined with the amino acid that binds to the substrate, this increases the rate of reaction, thermodynamics of reactions, for any reaction to happen, the g (free energy) must be negative: Gibbs free energy of final state must be lower than gibbs free energy of initial state. Even with a negative g, some reactions don"t occur readily. Energy made in the exergonic process can be coupled to the endergonic process. Enzyme substrate enzyme product is where the product of formed. Enzyme + product is the end result because the product is formed and the enzyme is not used up.
