PSYC1005 Lecture Notes - Lecture 12: Firstline, Antidepressant, Reuptake
PSYC 1005: Interventions for the treatment of psychological problems
DSM-5 (Criterion-based diagnosis):
Major depression
→ Depressed mod or loss of interest/ pleasure in all activities for more than 2 weeks,
clinical-significant distress or impairment in social, occupational or other functioning
→ At least four other symptoms:
o Somatic symptoms (changes in appetite, sleep and psychomotor activity,
fatigue)
o Neuropsychological change (difficult thinking, concentrating and making
decisions)
o Affective/cognitive changes (feelings of worthlessness, guilt, suicidal
ideation)
Anxiety
→ Excessive anxieties/worries
→ Anxiety, depression, sleep problems and fatigue are highly co morbid symptoms
correlated (i.e. symptoms occur together more often than they occur alone)
→ 1 in 5 Australians experience depression in their lifetime
→ Most common mental health problem in 12-25 year olds/youth
→ Increased risk of death – die on average 7.9 years earlier than others (US National
Health Interview Survey 1999)
Brain changes in depressed people
→ Prolonged/repeated stress + major depression are linked to changes in
o Cerebral blood flow
o Cerebral metabolism
o Structural abnormalities in the brain
• FMRI studies: decreased blood flow & cerebral metabolisms in
prefrontal cortex and hippocampus
• Post-mortem: decreased size in
→ Depression is a state of limbic-cortical deregulation (i.e. brain areas most affected)
that involves centres for memory, emotion and motivation which is caused by brain
cell death and immune system activation
→ What is causing this brain atrophy/inflammation?
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Document Summary
Psyc 1005: interventions for the treatment of psychological problems. Depressed mod or loss of interest/ pleasure in all activities for more than 2 weeks, clinical-significant distress or impairment in social, occupational or other functioning. At least four other symptoms: somatic symptoms (changes in appetite, sleep and psychomotor activity, fatigue, neuropsychological change (difficult thinking, concentrating and making decisions, affective/cognitive changes (feelings of worthlessness, guilt, suicidal ideation) Anxiety, depression, sleep problems and fatigue are highly co morbid symptoms correlated (i. e. symptoms occur together more often than they occur alone) 1 in 5 australians experience depression in their lifetime. Most common mental health problem in 12-25 year olds/youth. Increased risk of death die on average 7. 9 years earlier than others (us national. Prolonged/repeated stress + major depression are linked to changes in: cerebral blood flow, cerebral metabolism, structural abnormalities in the brain, fmri studies: decreased blood flow & cerebral metabolisms in prefrontal cortex and hippocampus, post-mortem: decreased size in.
