NEUR3101 Lecture Notes - Lecture 26: Serotonergic, Sensory Neuron, Motor Neuron
Document Summary
Activating pka - enhance the pre-synaptic neurons ability to release neurotransmitters. Synapse can grow with ltp - more ampa channels/more effective receptors. Rates will need to swim around until they find the one platform. Initially, they swim around trying to find platform. When removed from pool and put in again, they will make a direct b-line to the platform. Injection of an nmda-receptor blocker into the hippocampus of rats that were being trained in a water maze made them fail to learn the location of the escape platform. They are not as good at remembering - this effects their behaviour when they are put back into the liquid. Tonegawa and colleagues knocked out (deleted) the gene for one subunit of camkii (the protein kinase involved in ltp) and found deficits in both ltp and memory. Effects might go beyond the cascade that you are targeting. Growing up without a particular protein may cause developmental abnormalities.
