NEUR3101 Lecture Notes - Lecture 5: Voltage Clamp, Resting Potential, Current Clamp
Document Summary
Tremendous diversity in ap firing patterns in different regions. Information is moved around by aps, and somehow encoded in the rate or timing of aps. Study the hodgkin huxley model - all three share nobel price. Inflates body with sea water through a funnel. Needs fast propagation of aps in the muscle for fast contraction of whole muscle. Have really big axons - 1mm in thickness. Has an electrode in it, the axon is the whole thing. They showed there was 2 currents - na+ and k+ More sodium conductance than potassium conductance - resting potential. Na+ channels activate - upswing in ap - na+ conduction dominates. Na+ inactivate (despite positive voltage), gna activates (this is the gate) All these terms introduced by h and h. Why is better to fix vm and measure im. By fixing vm with voltage clamp you don"t have to worry about "g" changing with vm while you are measuring it.
