NEUR3101 Lecture Notes - Lecture 8: Intelligent Design, Dynamin, Synaptotagmin 1
Document Summary
This diagram is old - this is complex, but its more complex now. Proteins in the presynaptic membrane, post synaptic membrane (receptors, etc) and some in the cleft too. Alan finkle - neuroscientist at anu - in awe of nature (radio talk) It"s an evolved structure with redundant proteins etc, probably more complex than it needs to be. Some vesicles parked along membrane, some further up. Three pools of svs depending on how readily they can be released. ~200 svs in a typical hippocampal presynaptic terminal. Only about 10 of these (5%) are immediately available for release. The majority of svs (~85%) seem to be held in reserve. Not all svs participate equally in the sv cycle. Stimulus encountered: ap -> ca2+ comes in -> fusion -> release of transmitter. Fusion -> full collapse of vesicle into membrane. Needs to be reconstructed so that membrane area doesn"t just grow -> recover the added piece of membrane.
