NEUR3101 Lecture Notes - Lecture 3: Ion Channel, Depolarization, Ion
Document Summary
Even when depolarisation is maintained, the channels close again, it is self-limiting, so current increases and then decreases again. Based on aa sequencing - very common now since it is very cheap. Used to discover "new" ion channels based on homology with known channel. Often more interested in the function - although this is still useful. Normal script - ion permeable to the channel. Subscript - the stimuli that causes the channel to gate/open. These are k channels, that are activated by ca2+ First part is the name of the agonist. The channel is a single polypeptide with 4 homologous domains (i-iv) These are separate subunits, all part of the one massive peptide. Although, these do act like other channels with multiple different peptide units. Has an area of the single peptide that has the characteristics of a typical p-loop. One is the voltage sensor (see purple ivs4)
