BIOL1003 Lecture Notes - Lecture 1: Population Genetics, Sickle-Cell Disease, Achromatopsia
Document Summary
Population: localised group of freely interbreeding organisms that belong to the same species. Gene flow: movement of genes between populations as a result of migration/gamete disperesal. Gene pool: sum total of all genes + their alleles present in a pop. =(cid:3041)(cid:3042). (cid:3042)(cid:3033) (cid:3034)(cid:3032)(cid:3041)(cid:3042)(cid:3047)(cid:3043)(cid:3032)(cid:3046) (cid:4666)(cid:3032)(cid:3034). (cid:4667) (cid:3047)(cid:3042)(cid:3047)(cid:3028)(cid:3039) (cid:3041)(cid:3048)(cid:3040)(cid:3029)(cid:3032)(cid:3045) (cid:1868)2+(cid:884)(cid:1868)(cid:1869)+(cid:1869)2=(cid:883) H-w law if met allele freq + geno freq = constant. *genotype freq. determined by allele freq. of prev. generation: pop is large, no mig / gene flow, random mating, no natural selection, no mutations. Revert back to hw equil in next generation: are recessives (cid:858)hide out(cid:859) in heterozygotes, selecion against rarre recess. *change in freq. of alleles in a population. Things that result is s in allelic freq: random sampling. Drift eg. stoneflies: random s in allelic freq in a pop as a result of random variation in reporductive successs, loss of genetic variation, more marked in small populations.
