CHEM 1103 Study Guide - Midterm Guide: Urea Cycle, Half-Life, Biliverdin
1 Mar 2019
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Document Summary
Nitrogen metabolism: our bodies do not really have a nitrogen-storing molecule or complex. These range from minutes to years: purposes of protein turnover: Metabolic flexibility because of rapid changes in protein concentration. Protects cells from accumulation of abnormal proteins. Some cellular processes depend upon timely degradation of specific proteins (e. g. , cyclins and the cell cycle) N-terminal residues (n-end rule: several factors can contribute to the turnover of proteins: Protein stability can be estimated by knowing the n-terminal residue. Basic or bulky hydrophobic n-terminal residues are less stable. Sulfur- or hydroxyl-containing or nonbulky hydrophobic residues are found on more stable proteins. Specific protein sequences can cause a protein to be rapidly degraded (some. Some amino acids are altered by oxidases or by ross; this promotes protein sequences ensure rapid ubiquitination) degradation. E3 ubiquitin ligase (many versions are specific to proteins or protein classes)
