Problem 19

Cell migration entails the development of an actin-rich leading edge at the cell's front, the production of backward-moving focal adhesions and their subsequent release, as well as rear contraction to propel the cell onward.

The coordination of motions generated in diverse sections of a cell, together with a guided endocytic cycle, results in cell migration.

A directed endocytic cycle transports membrane and adhesion molecules from the back of the cell to the front, allowing the cell to migrate.